Long-Acting Muscarinic Antagonists for Difficult-to-Treat Asthma: Emerging Evidence and Future Directions
| Autor: | Farnaz Tabatabaian, Thomas B. Casale, Adeeb A. Bulkhi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Muscarinic Antagonists Pharmacology Anti-asthmatic Agent 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Parasympathetic Nervous System Muscarinic acetylcholine receptor medicine Humans Pharmacology (medical) Anti-Asthmatic Agents 030212 general & internal medicine Tiotropium Bromide Intensive care medicine Asthma business.industry Respiratory disease Receptor Cross-Talk Tiotropium bromide medicine.disease Receptors Muscarinic Acetylcholine respiratory tract diseases medicine.anatomical_structure 030228 respiratory system Delayed-Action Preparations Drug Therapy Combination Bronchoconstriction medicine.symptom business Respiratory tract medicine.drug |
| Zdroj: | Drugs. 76:999-1013 |
| ISSN: | 1179-1950 0012-6667 |
| Popis: | Asthma is a complex disease where many patients remain symptomatic despite guideline-directed therapy. This suggests an unmet need for alternative treatment approaches. Understanding the physiological role of muscarinic receptors and the parasympathetic nervous system in the respiratory tract will provide a foundation of alternative therapeutics in asthma. Currently, several long-acting muscarinic antagonists (LAMAs) are on the market for the treatment of respiratory diseases. Many studies have shown the effectiveness of tiotropium, a LAMA, as add-on therapy in uncontrolled asthma. These studies led to FDA approval for tiotropium use in asthma. In this review, we discuss how the neurotransmitter acetylcholine itself contributes to inflammation, bronchoconstriction, and remodeling in asthma. We further describe the current clinical studies evaluating LAMAs in adult and adolescent patients with asthma, providing a comprehensive review of the current known physiological benefits of LAMAs in respiratory disease. |
| Databáze: | OpenAIRE |
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