Labour characteristics and uterine activity: misoprostol compared with oxytocin in women at term with prelabour rupture of the membranes
| Autor: | Yik Ming Chan, Suk Wai Ngai, Sze Wing Lam, Terence T. Lao |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Fetal Membranes Premature Rupture medicine.medical_specialty Uterus Administration Oral Oxytocin Uterine Contraction Obstetrics and gynaecology Pregnancy Oxytocics medicine Humans Rupture of membranes Labor Induced Prospective Studies Prospective cohort study Misoprostol Gynecology business.industry Obstetrics Pregnancy Outcome Obstetrics and Gynecology medicine.disease Pregnancy Complications Parity medicine.anatomical_structure In utero Female business medicine.drug |
| Zdroj: | BJOG: An International Journal of Obstetrics and Gynaecology. 107:222-227 |
| ISSN: | 1471-0528 1470-0328 |
| DOI: | 10.1111/j.1471-0528.2000.tb11693.x |
| Popis: | Objective To compare the labour pattern and uterine activity of oral misoprostol with oxytocin for labour induction in women presenting with prelabour rupture of membranes at term. Design Prospective randomised study. Setting Department of Obstetrics and Gynaecology, Queen Mary Hospital, Hong Kong. Participants Eighty women presenting with prelabour rupture of membranes at term. Methods The women were randomised to receive either 100 μg misoprostol orally every 4 hours to a maximum of three doses, or intravenous oxytocin infusion according to the hospital protocol. Intrauterine pressure transducers were inserted one hour before induction of labour in both groups of women. We compared the pattern of uterine activity, the induction-to-delivery interval, duration of labour, mode of delivery and neonatal outcome between the two groups. Results Both oxytocin and oral misoprostol caused an increase in uterine activity within one hour of labour induction. Peak uterine activity was reached 6–8 h after oral misoprostol, with persistent effects, and 8–10 h after oxytocin, requiring continuous titration of medication. The duration of labour was significantly reduced in nulliparous women, but not in those who were multiparous in the misoprostol group. The induction-to-delivery interval, the mode of delivery and the perinatal outcome were similar for the two groups. Conclusion Oral misoprostol caused earlier peak uterine activity, compared with oxytocin (6–8 h vs 8–10 h). Oral misoprostol was not only as effective as oxytocin in inducing labour in women at term with prelabour rupture of the membranes, but it reduced significantly the duration of labour in nulliparous women. |
| Databáze: | OpenAIRE |
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