Neonatal Intrahippocampal Immune Challenge Alters Dopamine Modulation of Prefrontal Cortical Interneurons in Adult Rats
| Autor: | Carlos Feleder, Gwendolyn G. Calhoon, Kuei Y. Tseng, Patricio O'Donnell |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Lipopolysaccharides
Reflex Startle Startle response Patch-Clamp Techniques Quinpirole Interneuron Dopamine Action Potentials Prefrontal Cortex Hippocampus Enzyme-Linked Immunosorbent Assay Article Lesion Interneurons medicine Animals Prefrontal cortex Biological Psychiatry Prepulse inhibition medicine.diagnostic_test Gene Expression Regulation Developmental Neural Inhibition Startle reaction Rats medicine.anatomical_structure Acoustic Stimulation Animals Newborn Dopamine Agonists Cytokines medicine.symptom Psychology Neuroscience medicine.drug |
| Zdroj: | Biological Psychiatry. 67:386-392 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2009.09.028 |
| Popis: | Background Among the diverse animal models proposed for schizophrenia, the neonatal ventral hippocampal lesion (NVHL) is one of the most widely used. However, its construct validity can be questioned because there is no evidence of a lesion present in schizophrenia. Other approaches that have tried to capture environmental influences on development include diverse models of maternal infection. Methods As the early postnatal days in rodents are equivalent to the third trimester of human pregnancy in terms of brain development, we decided to test whether a neonatal immune challenge with an injection of the bacterial endotoxin lipopolysaccharide (LPS) into the ventral hippocampus caused deficits in interneuron function similar to those reported for the NVHL. Results Neonatal LPS injection caused a persistent elevation in cytokines in several brain regions, deficits in prepulse inhibition of the acoustic startle response, and a loss of the periadolescent maturation in the response of prefrontal cortical fast-spiking interneurons to dopamine. Conclusions The same phenotypes elicited by a NVHL can be obtained with an intrahippocampal immune challenge, suggesting that perinatal environmental factors can affect adult prefrontal interneuron maturation during adolescence. |
| Databáze: | OpenAIRE |
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