Melanocytic lesions with peripheral globules: results of an observational prospective study in 154 high‐risk melanoma patients under digital dermoscopy follow‐up evaluated with reflectance confocal microscopy

Autor: Elia Pérez-Fernández, Reyes Gamo-Villegas, F. Pinedo-Moraleda, Ana Pampín-Franco, Uxúa Floristán-Muruzábal, José Luis López-Estebaranz
Rok vydání: 2021
Předmět:
Zdroj: Journal of the European Academy of Dermatology and Venereology. 35:1133-1142
ISSN: 1468-3083
0926-9959
Popis: BACKGROUND The management of melanocytic lesions with peripheral globules (MLPGs) is usually age-dependent and can be challenging in high-risk melanoma patients. OBJECTIVES To evaluate clinical, dermoscopic and reflectance confocal microscopy (RCM) features of MLPG in patients under digital dermoscopic surveillance. To know whether dermoscopic or RCM findings correlate with histologic diagnosis and the accuracy of the dermoscopy-RCM compared with histopathology. METHODS During 24 months, we prospectively enrolled MLPG in patients under digital dermoscopy follow-up. All were evaluated by dermoscopy and RCM and excised for histologic examination. RESULTS We enrolled 154 patients, mean age 42.45 years (18.78-73.19). Three melanomas and 19 dysplastic naevi (DNs) were diagnosed. There were no significant differences in the age of the patients (P = 0.662). MLPGs with diameter of 6 mm or more and asymmetry in two axes were associated with melanoma (P = 0.01, P = 0.003). Patients with more than one MLPG were less likely to have melanoma. Blue-grey and red colours were more frequent in melanoma (P = 0.013 and P = 0.000). Different sizes and shapes of PG were associated with DN and melanoma (P = 0.000 and P = 0.001). In a new lesion, PG in
Databáze: OpenAIRE
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