First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases
| Autor: | T. A. Flaherty, A. Myers, J. R. Kendra, L. Russell, A. Barton, N. Horsfield, F. P. Rugman |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Chemotherapy Cytokine Therapy Chlorpromazine Neutrophils business.industry medicine.medical_treatment Granulocytosis General Medicine Middle Aged medicine.disease Uncommon disorder Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor Toxicity Immunology Humans Medicine Female In patient business Research Article Agranulocytosis medicine.drug |
| Zdroj: | Postgraduate Medical Journal. 69:885-887 |
| ISSN: | 1469-0756 0032-5473 |
| DOI: | 10.1136/pgmj.69.817.885 |
| Popis: | Summary Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role for such cytokine therapy in patients with life-threatening agranulocytosis in order to speed the recovery of neutrophils. |
| Databáze: | OpenAIRE |
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