Effects ofAPOE e4‐allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe )
| Autor: | Hendrik van den Bussche, Francisca S. Rodriguez, Birgitt Wiese, Christian Brettschneider, Alexander Pabst, Michael Pentzek, Steffen Wolfsgruber, Michael Wagner, Jochen Werle, Hans-Helmut König, Luca Kleineidam, Martin Scherer, Dagmar Lühmann, Steffi G. Riedel-Heller, Horst Bickel, Angela Fuchs, Dagmar Weeg, Siegfried Weyerer, Susanne Roehr, Wolfgang Maier |
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| Rok vydání: | 2020 |
| Předmět: |
Gerontology
Aging Apolipoprotein E4 Population Affect (psychology) mental demands cognitive functioning 03 medical and health sciences Apolipoproteins E Cognition 0302 clinical medicine genetics [Dementia] medicine risk factors Humans Dementia Cognitive Dysfunction ddc:610 Cognitive skill Cognitive decline education genetics [Apolipoprotein E4] Alleles Aged Language Cognitive reserve education.field_of_study Primary Health Care 030214 geriatrics genetics [Cognitive Dysfunction] longitudinal cohort study work environment cognitive reserve medicine.disease ddc Psychiatry and Mental health genetics [Apolipoproteins E] Marital status Geriatrics and Gerontology Psychology |
| Zdroj: | International journal of geriatric psychiatry 36(1), 152-162 (2021). doi:10.1002/gps.5409 |
| ISSN: | 1099-1166 0885-6230 |
| DOI: | 10.1002/gps.5409 |
| Popis: | Objectives Previous studies have observed protective effects of high mental demands at work on cognitive functioning and dementia risk. However, it is unclear what types of demands drive this effect and whether this effect is subject to a person's genetic risk. We investigated to what extent eight different types of mental demands at work together with the APOE e4 allele, a major risk gene for late-onset Alzheimer's disease, affect cognitive functioning in late life. Methods/design The population-based German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe, n=2,154) followed cognitively healthy individuals aged 75 years and older in seven assessment waves. Cognitive functioning was assessed via the mini-mental status examination. Results Mixed-effects modeling (adjusted for education, gender, marital status, stroke, depression, and diabetes) indicated that participants who had an occupational history of working in jobs with high compared to low demands in 'Language & Knowledge', 'Pattern detection', 'Information processing', and 'Service' had a slower cognitive decline. APOE e4-allele carriers had an accelerated cognitive decline, but this decline was significantly smaller if they had a medium compared to a low level of demands in contrast to non-carriers. Conclusions Our longitudinal observations suggest that cognitive decline could be slowed by an intellectually enriched lifestyle even in risk gene carriers. Fostering intellectual engagement throughout the life-course could be a key prevention initiative to promote better cognitive health in old age. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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