Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies

Autor:	Binghe Wang, Qinchao Cai, Claudio Feliciani, Irwin Freed, Daniel N. Sauder
Rok vydání:	2001
Předmět:	Mice Knockout Immunology Contact hypersensitivity Cell Biology Biology Dermatitis Contact Cell biology Mice Immune system Immune System Knockout mouse Immunology and Allergy Animals Gene knockout
Zdroj:	Journal of leukocyte biology. 70(2)
ISSN:	0741-5400
Popis:	Contact hypersensitivity (CHS), a dendritic-cell (DC)-dependent, T-cell-mediated skin immune response to reactive haptens, has been a subject of intense research for many years. The molecular mechanisms underlying CHS are complicated and are not fully understood. During the past few years, varieties of gene-targeted knockout mice have been used in the study of CHS. Such studies have contributed significantly to our understanding of the mechanisms responsible for the initiation of CHS. This review focuses on insights into molecular requirements for CHS gained from knockout studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7614cc570b9bf05eaf15298b5b8b2b43 https://pubmed.ncbi.nlm.nih.gov/11493609 Zobrazit plný text záznamu Plný text