Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease

Autor: Danielle Gulick, Laura J. Blair, Santiago Rodriguez Ospina, Jeremy D. Baker, Ilayda Ozsan
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Receptors
Steroid
steroid hormones
medicine.medical_treatment
Review
lcsh:Chemistry
Cyclophilins
0302 clinical medicine
Glucocorticoid receptor
CyP40
Receptor
lcsh:QH301-705.5
Spectroscopy
molecular chaperones
PP5
General Medicine
Hsp90
Computer Science Applications
Circadian Rhythm
GR
Signal Transduction
medicine.medical_specialty
psychiatric disease
Biology
Catalysis
Inorganic Chemistry
Tacrolimus Binding Proteins
03 medical and health sciences
Internal medicine
Heat shock protein
medicine
Humans
HSP90 Heat-Shock Proteins
Physical and Theoretical Chemistry
Molecular Biology
Transcription factor
Glycoproteins
Depressive Disorder
Major
Organic Chemistry
stress response
FKBP52
Steroid hormone
030104 developmental biology
Endocrinology
FKBP51
lcsh:Biology (General)
lcsh:QD1-999
circadian rhythms
biology.protein
030217 neurology & neurosurgery
Hormone
Zdroj: International Journal of Molecular Sciences, Vol 20, Iss 1, p 79 (2018)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: The hypothalamus-pituitary-adrenal (HPA) axis directly controls the stress response. Dysregulation of this neuroendocrine system is a common feature among psychiatric disorders. Steroid hormone receptors, like glucocorticoid receptor (GR), function as transcription factors of a diverse set of genes upon activation. This activity is regulated by molecular chaperone heterocomplexes. Much is known about the structure and function of these GR/heterocomplexes. There is strong evidence suggesting altered regulation of steroid receptor hormones by chaperones, particularly the 51 kDa FK506-binding protein (FKBP51), may work with environmental factors to increase susceptibility to various psychiatric illnesses including post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety. This review highlights the regulation of steroid receptor dynamics by the 90kDa heat shock protein (Hsp90)/cochaperone heterocomplexes with an in depth look at how the structural regulation and imbalances in cochaperones can cause functional effects on GR activity. Links between the stress response and circadian systems and the development of novel chaperone-targeting therapeutics are also discussed.
Databáze: OpenAIRE
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