Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial
| Autor: | Yoshikazu Kinoshita, Maho Kusunoki, Isao Ikuma, Yoshiya Kobayashi, Yoshinori Komazawa, Yoshiko Takahashi, Sayaka Nakashima, Toshihiro Shizuku, Mika Yuki, Goichi Uno |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Constipation Visual analogue scale daikenchuto chronic constipation small intestinal bacterial overgrowth Single Center Gastroenterology Internal medicine Small intestinal bacterial overgrowth medicine Pharmacology (medical) Original Research Breath test Pharmacology Chronic constipation medicine.diagnostic_test business.industry lcsh:RM1-950 abdominal bloating medicine.disease Indigestion Clinical trial lcsh:Therapeutics. Pharmacology medicine.symptom business |
| Zdroj: | Current Therapeutic Research, Clinical and Experimental Current Therapeutic Research, Vol 77, Iss C, Pp 58-62 (2015) |
| ISSN: | 0011-393X |
| DOI: | 10.1016/j.curtheres.2015.04.002 |
| Popis: | Background Daikenchuto (DKT), a traditional Japanese herbal medicine, is widely used for treatment of gastrointestinal disorders. We evaluated the efficacy and safety of DKT for abdominal bloating in patients with chronic constipation. Objective To evaluate the efficacy and safety of DKT for the treatment of abdominal bloating. Methods After discontinuing as-needed use of laxatives, 10 patients received oral DKT for 14 days (15 g/d). To evaluate small intestinal bacteria overgrowth (SIBO), a glucose breath test was performed before and after treatment with DKT. Before beginning the treatment, 4 patients (40%) had a diagnosis of SIBO based on a positive glucose breath test result. In both the SIBO and non-SIBO groups, bowel movement frequency and stool form remained unchanged after DKT treatment. Results For all patients, median total Gastrointestinal Symptoms Rating Scale score and the median Gastrointestinal Symptoms Rating Scale indigestion and constipation subscales were significantly decreased, whereas the median visual analog score for decreased abdominal bloating was significantly increased. Improvements of those symptoms were the same in both the SIBO and non-SIBO groups, indicating that DKT does not have effects on small intestine bacteria. No serious side effects were reported. Conclusions DKT treatment improved quality of life for patients with chronic constipation regardless of the presence of SIBO and showed no effects on small intestine bacteria. UMIN Clinical Trial Registry identifier: UMIN000008070. |
| Databáze: | OpenAIRE |
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