Role of oligo(malic acid) on the formation of unilamellar vesicles
| Autor: | Judith Mihály, Pál Szabó, András Lőrincz, András Wacha, Imola Csilla Szigyártó, Zoltán Varga, Lívia Naszályi-Nagy, Sandor Kristyan, Attila Bóta, Miklós Kálmán |
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| Rok vydání: | 2018 |
| Předmět: |
1
2-Dipalmitoylphosphatidylcholine Cell Survival Polymers Surface Properties Lipid Bilayers Malates 02 engineering and technology 010402 general chemistry 01 natural sciences Cell Line Biomaterials chemistry.chemical_compound Hydrolysis Colloid and Surface Chemistry Humans Particle Size Lipid bilayer Unilamellar Liposomes chemistry.chemical_classification Liposome Vesicle food and beverages Polymer Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Cholesterol chemistry Dipalmitoylphosphatidylcholine Drug delivery Biophysics Nanoparticles lipids (amino acids peptides and proteins) Malic acid 0210 nano-technology |
| Zdroj: | Journal of colloid and interface science. 532 |
| ISSN: | 1095-7103 |
| Popis: | Stable unilamellar dipalmitoylphosphatidylcholine vesicles were produced by using oligo(malic acid) and cholesterol. Detailed physico-chemical characterization prove that by using oligo(malic acid) the substitution of PEGylated lipids for sterically stabilization comes possible. The polymer molecules cover the outer surface of spherical-shaped vesicles, and an asymmetrical composition occurs in the two leaflets of the phospholipid bilayer. The oligo(malic-acid) and cholesterol are enriched in the outer side assuring the stabilization of vesicles. Cholesterol plays an important role in the self-assembly of components as it makes the entering of oligomers possible deep into the polar head-region of lipids. The presence of oligo(malic acid) molecules does not induce degradation by hydrolysis of lipid molecules but the vesicle system turns into a sensitive form giving a possibility for pH sensitive targeting. Preliminary investigation on the investigated oligo(malic acid)-stabilized vesicles do not show any toxic effect promising their applicability in the field of liposomal drug delivery. |
| Databáze: | OpenAIRE |
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