Serum irisin concentration in women with gestational diabetes

Autor:	Szamatowicz M, Piotr Laudanski, Danuta Lipinska, Justyna Pliszka, Adam Kretowski, Juliusz Wilk, Jacek Szamatowicz, Beata Telejko, Mariusz Kuzmicki, Maria Gorska, Monika Zbucka-Kretowska
Rok vydání:	2014
Předmět:	Adult medicine.medical_specialty Endocrinology Diabetes and Metabolism Adipokine Endocrinology Insulin resistance Pregnancy Internal medicine Myokine medicine Humans Normal glucose tolerance business.industry Obstetrics and Gynecology Total body Glucose Tolerance Test medicine.disease Fibronectins Gestational diabetes Diabetes Gestational Cross-Sectional Studies Energy expenditure Case-Control Studies Female business
Zdroj:	Gynecological Endocrinology. 30:636-639
ISSN:	1473-0766 0951-3590
DOI:	10.3109/09513590.2014.920006
Popis:	Irisin is a novel myokine and adipokine which induces an increase in total body energy expenditure, improving insulin sensitivity and glucose tolerance in experimental animals. In the present study, serum irisin concentration was measured by an enzyme immunoassay in 130 women with gestational diabetes mellitus (GDM) and 140 BMI-matched patients with normal glucose tolerance (NGT). Median irisin level was significantly lower in the patients with GDM than in the NGT subjects (1703.3 [1354.8-2097.9 ng/ml] versus 1873.8 [1519.8-2294.8 ng/ml], p = 0.01); however, 3 months after childbirth its concentrations did not differ markedly between the two groups (1165.9 [872.1-1497.5] ng/ml versus 1139.0 [984.0-1376.7] ng/ml). In the whole group, irisin concentration correlated negatively with 2 h glucose level (R = -0.14, p = 0.03). In the women with NGT, irisin concentration correlated positively with IS(OGTT) (R = 0.22, p = 0.04) and the disposition index (DI(120)) (R = 0.24, p = 0.03), as well as negatively with 2 h insulin level (R = -0.23, p = 0.03) and HOMA-IR (R = -0.24, p = 0.02). Multiple regression analysis revealed that 2 h glucose and DI(120) were the only variables significantly influencing serum irisin (β = 0.158, p = 0.03 and β = 0.159, p = 0.02, respectively). Our results suggest that serum irisin concentration increases markedly in pregnant women, but this increase seems to be significantly lower in patients with GDM.
Databáze:	OpenAIRE
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