The impact of hydroxycitric acid on the lipid metabolism profile under experimental insulin resistance syndrome of Syrian hamsters
| Autor: | V. P. Fylymonenko, T. O. Briukhanova, A. L. Zagayko, A. I. Shkapo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty ATP citrate lyase government.form_of_government Hyperlipidemias Fructose Glucosephosphate Dehydrogenase Diet High-Fat Biochemistry lcsh:Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Blood serum Internal medicine Hyperlipidemia medicine Animals lcsh:QD415-436 Citrates Obesity Mesocricetus Lipid metabolism Lipase Syndrome medicine.disease Lipid Metabolism Hydroxycitric acid 030104 developmental biology Endocrinology chemistry Gene Expression Regulation Liver 030220 oncology & carcinogenesis Lipogenesis Lysosomal Lipase government ATP Citrate (pro-S)-Lyase Anti-Obesity Agents Insulin Resistance Lysosomes Oxidation-Reduction |
| Zdroj: | Ukrainian Biochemical Journal, Vol 88, Iss 3, Pp 78-83 (2016) |
| ISSN: | 2413-5003 2409-4943 |
| Popis: | The syndrome of insulin resistance (IR) is one of the leading reasons for the increased risk of cardiovascular diseases and their complications. Among the key components of IR are obesity and dyslipidemia. Hydroxycitric acid (HCA), an inhibitor of a key enzyme of lipogenesis ATP citrate lyase (ACLY) is a promising obesity treatment agent. The aim of this work was to investigate the effect of HCA on lipid and lipoproteins content in the blood serum, as well as lipid content and activity of some lipid metabolism enzymes in the liver of hamsters with IR. IR was modeled by keeping animals on high-fat diet with addition of fructose. Lipid content was determined by using standard reagent kits, the level of lipoproteins, the activity of glucose 6-phosphate dehydrogenase and ACLY – spectrophotometrically, lysosomal lipase activity – fluorimetrically. Development of hyperlipidemia and atherogenic dyslipidemia, lipid accumulation in the liver, activation of lysosomal lipase and ACLY and reduction of glucose 6-phosphate dehydrogenase activity were shown under IR. The treatment by HCA reduces the manifestations of hyperlipidemia, but enhances the lipid accumulation in the liver. |
| Databáze: | OpenAIRE |
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