Presumable role of outer membrane proteins of Salmonella containing sialylated lipopolysaccharides serovar Ngozi, sv. Isaszeg and subspecies arizonae in determining susceptibility to human serum
| Autor: | Gabriela Bugla-Płoskońska, Elżbieta Klausa, Urszula Godlewska, Jacek Rybka, Bożena Futoma-Kołoch, Agata Dorotkiewicz-Jach, Katarzyna Guz-Regner |
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| Rok vydání: | 2015 |
| Předmět: |
Salmonella
Lipopolysaccharide Short Report Complement medicine.disease_cause Microbiology chemistry.chemical_compound Antigen Virology medicine C3 biology Gastroenterology biology.organism_classification Sialic acid Complement system Infectious Diseases chemistry Salmonella enterica Outer membrane protein Parasitology Bacterial outer membrane Salmonella O48 Bacteria |
| Zdroj: | Gut Pathogens |
| ISSN: | 1757-4749 |
| Popis: | Background The O48 group comprises Salmonella bacteria containing sialic acid in the lipopolysaccharide (LPS). Bacteria with sialylated surface structures are described as pathogens that avoid immunological response of the host by making similar their surface antigens to the host’s tissues (molecular mimicry). It is known that the smooth-type LPS of Salmonella enterica and outer membrane proteins (OMP) PgtE, PagC and Rck mediate serum resistant phenotype by affecting complement system (C). The aim of this study was to investigate C3 component activation by Salmonella O48 LPS and OMP. Findings In the present study, we examined C3 component deposition on the three Salmonella O48 strains: S. enterica subspecies enterica serovar Ngozi, S. enterica subsp. enterica sv. Isaszeg, and S.enterica subsp. arizonae containing sialic acid in the O-specific part of LPS. The greatest C3 deposition occurred on Salmonella sv. Isaszeg cells (p |
| Databáze: | OpenAIRE |
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