Anatomical substrates and neurocognitive predictors of daily numerical abilities in mild cognitive impairment
| Autor: | Brian Butterworth, Giorgio Arcara, Francesca Meneghello, Francesca Burgio, Annalena Venneri, Matteo De Marco, Silvia Benavides-Varela, Carlo Semenza, Cristina Pilosio, Jessica Rigon |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Cognitive Neuroscience Experimental and Cognitive Psychology Audiology Cognitive neuroscience Neuropsychological Tests 050105 experimental psychology 03 medical and health sciences Cognitive aging 0302 clinical medicine Cognition Compensatory reorganization MCI mild cognitive impairment Money usage and time estimation deficit Numerical deficits in ecological contexts Neuropsychology and Physiological Psychology Predictive Value of Tests Activities of Daily Living medicine Humans 0501 psychology and cognitive sciences Cognitive Dysfunction Neuropsychological assessment Gray Matter Cognitive neuropsychology Aged Temporal cortex Aged 80 and over Brain Mapping Language Tests medicine.diagnostic_test 05 social sciences Neuropsychology Frontal gyrus Magnetic Resonance Imaging White Matter Female Psychology Neurocognitive 030217 neurology & neurosurgery Mathematics Cognitive psychology |
| ISSN: | 1387-2877 |
| Popis: | Patients with mild cognitive impairment experience difficulties in mathematics that affect their functioning in the activities of everyday life. What are the associated anatomical brain changes and the cognitive correlates underlying such deficits? In the present study, 33 patients with Mild Cognitive Impairments (MCI) and 29 cognitively normal controls underwent volumetric MRI, and completed the standardized battery of Numerical Activities of Daily Living (NADL) along with a comprehensive clinical neuropsychological assessment. Group differences were examined on the numerical tasks and volumetric brain measures. The gray (GM) and white matter (WM) volume correlates were also evaluated. The results showed that relative to controls, the MCI group had impairments in number comprehension, transcoding, written operations, and in daily activities involving time estimation and money usage. In the volumetric measures, group differences emerged for the transcoding subtask in the left insula and left superior temporal gyrus. Among MCI patients, number comprehension and formal numerical performance were correlated with volumetric variability in the right middle occipital areas and right frontal gyrus. Money-usage scores showed significant correlations with left mesial frontal cortex, right superior frontal and right superior temporal cortex. Regression models revealed that neuropsychological measures of long-term memory, language, visuo-spatial abilities, and abstract reasoning were predictive of the patients' decline in daily activities. The present findings suggest that early neuropathology in distributed cortical regions of the brain including frontal, temporal and occipital areas leads to a breakdown of cognitive abilities in MCI that impacts on numerical daily functioning. The findings have implications for diagnosis, clinical and domestic care of patients with MCI. |
| Databáze: | OpenAIRE |
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