Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study

Autor: Leerink, J.M., Feijen, E.L.A.M., Pal, H.J.H. van der, Kok, W.E.M., Mavinkurve-Groothuis, A.M.C., Kapusta, L., Pinto, Y.M., Maas, A.H.E.M., Bellersen, L., Teske, A.J., Ronckers, C.M., Louwerens, M., Dalen, E.C. van, Dulmen-den Broeder, E. van, Batenburg, L., Heiden-van der Loo, M. van der, Heuvel-Eibrink, M.M. van den, Leeuwen, F.E. van, Vries, A.C.H. de, Weijers, G., Korte, C.L. de, Loonen, J.J., Neggers, S.J.C.M.M., Versluys, A.B.B., Tissing, W.J.E., Kremer, L.C.M., Grootenhuis, M.A., Hartogh, J.G. den, Santen, H. van, LATER Study Grp
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Pediatrics, Internal Medicine, Pediatric surgery, CCA - Cancer Treatment and quality of life, Amsterdam Reproduction & Development (AR&D)
Rok vydání: 2020
Předmět:
Male
Cross-sectional study
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Apoptosis
ADULT SURVIVORS
030204 cardiovascular system & hematology
Electrocardiography
Ventricular Dysfunction
Left
0302 clinical medicine
Cancer Survivors
Risk Factors
Neoplasms
Myocytes
Cardiac
030212 general & internal medicine
Child
AMERICAN SOCIETY
Subclinical infection
Netherlands
medicine.diagnostic_test
Ventricular Remodeling
DIASTOLIC DYSFUNCTION
Cardiovascular physiology
Echocardiography
CARDIOVASCULAR-DISEASE
Child
Preschool
Cardiology
HEART-FAILURE
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Adolescent
Heart Diseases
Lower risk
Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
EJECTION FRACTION
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
SDG 3 - Good Health and Well-being
Internal medicine
medicine
Journal Article
Humans
Ventricular remodeling
Heart Failure
Inflammation
EUROPEAN ASSOCIATION
business.industry
MORTALITY
fungi
Infant
Newborn
Cancer
Infant
5-YEAR SURVIVORS
medicine.disease
Oxidative Stress
Cross-Sectional Studies
Early Diagnosis
Heart failure
business
FOLLOW-UP
Biomarkers
Zdroj: American Heart Journal, 219, 89-98
American Heart Journal, 219, 89. Mosby Inc.
Leerink, J M, Feijen, E L A M, van der Pal, H J H, Kok, W E M, Mavinkurve-Groothuis, A M C, Kapusta, L, Pinto, Y M, Maas, A H E M, Bellersen, L, Teske, A J, Ronckers, C M, Louwerens, M, van Dalen, E C, van Dulmen-den Broeder, E, Batenburg, L, van der Heiden-van der Loo, M, van den Heuvel-Eibrink, M M, van Leeuwen, F E, de Vries, A C H, Weijers, G, de Korte, C L, Loonen, J J, Neggers, S J C M M, Versluys, A B B, Tissing, W J E, Kremer, L C M & on behalf of the LATER Study Group 2020, ' Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors : Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study ', American Heart Journal, vol. 219, pp. 89-98 . https://doi.org/10.1016/j.ahj.2019.10.010
American Heart Journal, 219, 89-98. MOSBY-ELSEVIER
American Heart Journal, 219, 89-98. Mosby Inc.
American Heart Journal, 219, pp. 89-98
ISSN: 0002-8703
DOI: 10.1016/j.ahj.2019.10.010
Popis: Background Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure.Objective To describe the methodology of the Dutch LATER cardiology study (LATER CARD).Methods The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings.Conclusions The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.
Databáze: OpenAIRE
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