Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome
| Autor: | Jesna Jose, Ahmed Abdulmomen, Ahmed Mady, Sarah Shalhoub, Ghaleb A. Almekhlafi, Yaseen M. Arabi, Hanan H. Balkhy, Basem Alraddadi, Haytham Tlayjeh, Othman Solaiman, Robert A. Fowler, Abdulsalam M. Al-Aithan, Ismael Qushmaq, Kasim Al Khatib, Rajaa Al-Raddadi, Musharaf Sadat, Fahad Al-Hameed, Abdullah Almotairi, Frederick G. Hayden, Ayman Kharaba, Yasser Mandourah, Ahmed Ragab, Laura Merson, Awad Al-Omari, Abdulrahman Al Harthy |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Epidemiology medicine.medical_treatment Critical Illness coronavirus Saudi Arabia medicine Intubation pneumonia Humans Treatment Failure Aged Retrospective Studies Mechanical ventilation Respiratory Distress Syndrome Noninvasive Ventilation medicine.diagnostic_test business.industry Middle East respiratory syndrome Public Health Environmental and Occupational Health Odds ratio Original Articles acute respiratory distress syndrome Middle Aged medicine.disease Pneumonia Intensive Care Units Treatment Outcome Infectious Diseases Anesthesia Noninvasive ventilation SOFA score Original Article Female Chest radiograph business Coronavirus Infections severe acute respiratory infection |
| Zdroj: | Influenza and Other Respiratory Viruses |
| DOI: | 10.1111/irv.12635 |
| Popis: | Background: Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.Methods: Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV).Results: Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90‐day mortality (propensity score‐adjusted odds ratio 0.61, 95% CI [0.23, 1.60] P = 0.27).Conclusions: In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes. |
| Databáze: | OpenAIRE |
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