The coming impact of gene expression profiling on the diagnosis and treatment of HCV-associated liver disease
| Autor: | Andrea D. Branch, Jose L. Walewski |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pharmacology
Gene Expression Profiling Hepatitis C virus Hepatitis C Computational biology Biology medicine.disease Molecular diagnostics medicine.disease_cause Virology Gene expression profiling Liver disease Liver Gene expression medicine Humans DNA microarray Gene Oligonucleotide Array Sequence Analysis |
| Zdroj: | Antiviral Research. 52:173-179 |
| ISSN: | 0166-3542 |
| DOI: | 10.1016/s0166-3542(01)00182-6 |
| Popis: | Gene expression profiling allows the level of activity of thousands of genes to be monitored simultaneously. Profiling is often carried out on specialized chips or slides, which have microarrays of gene targets at predetermined addresses. In the immediate future, microarrays promise to yield new insights into hepatitis C virus (HCV) pathogenesis and to produce 'signatures' that can be used in molecular diagnostics. In the longer-term, they may aid the development of serological tests by identifying genes encoding secretory proteins produced by HCV-infected livers, and they may suggest new avenues for disease intervention by detecting genes whose products are retained in the infected liver. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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