The effect of tactivin on analgesia induced by acute and chronic immobilization

Autor: O. V. Belova, A. V. Novoseletskaya, A. N. Inozemtsev, V. Ya. Arion, V. I. Sergienko, N. M. Kiseleva, I. V. Zimina
Rok vydání: 2014
Předmět:
Zdroj: Doklady Biological Sciences. 458:275-277
ISSN: 1608-3105
0012-4966
DOI: 10.1134/s0012496614050093
Popis: Many studies on neuroimmunophysiology have recently been carried out (1). The immune system is known to take an active part in the antistress system of the body (2). The thymus plays the central role in the immune system by producing hormones and pep� tides. In the early 1970s, many immunoactive sub� stances were extracted from the thymus, including tac� tivin, which contains lowmolecularweight peptides and polypeptides (3). Earlier studies were aimed at modulating stress in different models using tactivin. Tactivin helped to recover the parameters of the immune system and remove intoxication by restoring homeostasis in rat models of acute general peritonitis and burning trauma, and subacute and chronic benzene intoxica� tion (4-6). Further studies showed that tactivin had an antistress effect during the emotional stress (7). Nevertheless, the molecular and neurochemical mechanisms of the antistress effect of tactivin were investigated only in one study, which suggested a neu� rochemical mechanism of the modulation of emo� tional stress by tactivin (8). The aim of our study was to investigate the effect of thymus polypeptides—tactivin—on pain sensitivity and to analyze the possible involvement of the opioid system in analgesia induced by immobilization stress.
Databáze: OpenAIRE
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