Reactions of Zinc Enolates Derived from 1-Aryl-2,2-di-bromoalkanones with 2-Acyl-3H-benzo[f]chromen-3-ones, 6-Bromo-2-oxochromene-3-carboxamides, and 3-Oxo-3H-benzo[f]chromene-2-carboxamides

Autor:	R. V. Shchepin, P. S. Silaichev, V. V. Shchepin, M. I. Kodess, M. M. Kalyuzhnyi, M. A. Ezhikova, N. Yu. Russkikh
Rok vydání:	2005
Předmět:	chemistry.chemical_compound Chemistry Aryl Organic Chemistry chemistry.chemical_element Organic chemistry Stereoselectivity General Medicine Zinc Medicinal chemistry
Zdroj:	ChemInform. 36
ISSN:	1522-2667 0931-7597
Popis:	Zinc enolates derived from substituted 1-aryl-2,2-dibromoalkanones reacted with 2-acyl-3H-benzo-[f]chromen-3-ones to give 1-alkyl-1-aroyl-1a-acyl-1a, 9c-dihydro-1H-3-oxacyclopropa[c]phenanthren-2-ones which were formed as a single stereoisomer. Reactions of the same zinc enolates with 6-bromo-2-oxo-chromene-3-carboxamides (piperidides and morpholides) afforded 1-aroyl-6-bromo-1-alkyl-1a-piperidino-(morpholino)carbonyl-1a,7b-dihydrocyclopropa[c]chromen-2-ones with high stereoselectivity. Likewise, 1-benzoyl-1-methyl-1a-morpholinocarbonyl-1a, 9c-dihydro-1H-3-oxacyclopropa[c]phenanthren-2-one was obtained by reac-tion with 3-oxo-3H-benzo[f]chromene-2-carboxylic acid morpholide.
Databáze:	OpenAIRE
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