Elevated C-Reactive Protein and Hypoalbuminemia Measured before Resection of Colorectal Liver Metastases Predict Postoperative Survival
| Autor: | Tomokazu Kishiki, Yoshiharu Takenaka, Takashi Kobayashi, Kaoru Kobayashi, Daisuke Endo, Kenji Miki, Masanori Teruya, Koji Morita |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Oncology medicine.medical_specialty Colorectal cancer Inflammation Kaplan-Meier Estimate Gastroenterology Metastasis Cohort Studies Postoperative Complications Predictive Value of Tests Internal medicine Preoperative Care Biomarkers Tumor Hepatectomy Humans Medicine Hypoalbuminemia Survival analysis Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Aged 80 and over Analysis of Variance business.industry Proportional hazards model Liver Neoplasms Retrospective cohort study Prognosis medicine.disease Survival Analysis C-Reactive Protein Treatment Outcome Predictive value of tests Multivariate Analysis Female Surgery medicine.symptom Colorectal Neoplasms business |
| Zdroj: | Digestive Surgery. 27:285-290 |
| ISSN: | 1421-9883 0253-4886 |
| DOI: | 10.1159/000280021 |
| Popis: | Background: Few studies have investigated whether the Glasgow Prognostic Score (GPS), an inflammation-based prognostic score measured before resection of colorectal liver metastasis (CRLM), can predict postoperative survival. Patients and Methods: Sixty-three consecutive patients who underwent curative resection for CRLM were investigated. GPS was calculated on the basis of admission data as follows: patients with both an elevated C-reactive protein (>10 mg/l) and hypoalbuminemia (Results: Significant factors concerning survival were the number of liver metastases (p = 0.0044), carcinoembryonic antigen level (p = 0.0191), GPS (p = 0.0029), grade of liver metastasis (p = 0.0033), and the number of lymph node metastases around the primary cancer (p = 0.0087). Multivariate analysis showed the two independent prognostic variables: liver metastases ≧3 (relative risk 2.83) and GPS1/2 (relative risk 3.07). Conclusions: GPS measured before operation and the number of liver metastases may be used as novel predictors of postoperative outcomes in patients who underwent curative resection for CRLM. |
| Databáze: | OpenAIRE |
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