Protective and therapeutic effects of molsidomine on radiation induced neural injury in rats
| Autor: | Onural Ozhan, Hakan Parlakpinar, Azibe Yildiz, M A Durak, Kemal Ekici, Alaadin Polat, Nigar Vardi, Muharrem Uçar, R Pasahan |
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| Rok vydání: | 2017 |
| Předmět: |
Histology
Antioxidant Molsidomine medicine.medical_treatment Radiation induced Radiation-Protective Agents Oxidative phosphorylation Pharmacology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Malondialdehyde Radiation Ionizing Mole medicine Animals Neuronal degeneration business.industry Superoxide Dismutase Therapeutic effect Brain General Medicine Glutathione Rats Medical Laboratory Technology Radiation Injuries Experimental chemistry 030220 oncology & carcinogenesis Anesthesia Female business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Biotechnichistochemistry : official publication of the Biological Stain Commission. 92(1) |
| ISSN: | 1473-7760 |
| Popis: | We investigated the protective and therapeutic effects of molsidomine (MOL) in a rat model of whole brain radiotherapy (RT). Forty female rats were divided into five groups of eight: group 1, control; group 2, 15 Gy single dose RT (RT); group 3, 4 mg/kg MOL treated for 5 days (MOL); group 4, 4 mg/kg MOL for 5 days, 10 days after RT treatment (RT + MOL); group 5, 4 mg/kg MOL treatment for 5 days before RT treatment and for 5 days after RT treatment (MOL + RT). All rats were sacrificed on day 16. Neurodegenerative changes in the brain and tissue levels of oxidants and antioxidants were evaluated. The oxidative parameters were increased and antioxidant status was decreased in group RT compared to groups MOL + RT and RT + MOL. Histopathological examination showed that treatment with MOL after RT application and treatment with MOL before RT treatment decreased neuronal degeneration. No difference in neuronal appearance was found between groups RT + MOL and MOL + RT. MOL treatment protected the nervous system of rats and may be a treatment option for preventing RT induced neural injury. |
| Databáze: | OpenAIRE |
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