Repeated administration of high dose levodopa enhances hydroxyl radical production in the rat striatum denervated with 6-hydroxydopamine
| Autor: | Yoshio Mitsuyama, Yasushi Ishida, Yuta Ishizuka, Kazunari Todaka, Hiroyuki Hashiguchi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Levodopa
Microdialysis Radical Striatum Pharmacology Drug Administration Schedule chemistry.chemical_compound Basal ganglia medicine Animals Rats Wistar Oxidopamine Hydroxydopamine Hydroxyl Radical General Neuroscience Denervation Corpus Striatum Rats chemistry Anesthesia Female Hydroxyl radical Injections Intraperitoneal medicine.drug |
| Zdroj: | Neuroscience Letters. 290:33-36 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(00)01320-3 |
| Popis: | We examined whether levodopa (L-DOPA) might increase production of hydroxyl radicals in intact and dopamine-denervated rat striatum. Salicylate trapping combined with in vivo microdialysis provided measurements of 2,3-dihydroxybenzoic acid (2,3-DHBA) as a marker of hydroxyl radical production. Acute administration of high-dose L-DOPA (200, 500 mg/kg, i.p.) did not alter 2,3-DHBA levels in intact striatum or in striatum denervated with 6-hydroxydopamine. On the other hand, L-DOPA administration (200 mg/kg, i.p.) transiently increased 2,3-DHBA in dopamine-denervated striatum of rats after repeated administration of L-DOPA (200 mg/kg, i.p., once daily for 16 days). The results indicated that repeated administration of high dose L-DOPA increased production of hydroxyl radicals in dopamine-denervated striatum. |
| Databáze: | OpenAIRE |
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