SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors

Autor:	Martin Kralik, Jan Mies, Michael Gassen, Johann Leban, Roland Baumgartner, Karin Tentschert
Rok vydání:	2005
Předmět:	Cellular activity Stereochemistry medicine.drug_class Carboxylic acid Heteroatom Clinical Biochemistry Pharmaceutical Science Carboxamide Cyclopentanes Ring (chemistry) Biochemistry chemistry.chemical_compound Inhibitory Concentration 50 Mice Structure-Activity Relationship Species Specificity Drug Discovery Side chain medicine Structure–activity relationship Cyclopentene Animals Humans Enzyme Inhibitors Molecular Biology Cell Proliferation Biphenyl chemistry.chemical_classification biology Dihydroorotate Oxidase Organic Chemistry General Medicine Amides Rats Enzyme Dicarboxylic acid chemistry Enzyme inhibitor Dihydroorotate dehydrogenase biology.protein Leukocytes Mononuclear Molecular Medicine Immunosuppressive Agents
Zdroj:	Bioorganicmedicinal chemistry letters. 15(21)
ISSN:	0960-894X
Popis:	Novel DHODH inhibitors were developed based on a previously described series by introduction of heteroatoms into the cyclopentene ring and hydroxyl groups attached to it. Also, the hydrophobic biphenyl side chain was replaced with benzyloxy phenyl groups. Activities on human, rat, and mouse enzymes indicate a species specificity of these inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753064c3881227f3f6aba3a49ca53e71 https://pubmed.ncbi.nlm.nih.gov/16143532 Zobrazit plný text záznamu Full Text from ScienceDirect