Intermittent androgen deprivation in prostate cancer cases with biochemical progression after radical prostatectomy: Are we ready to treat?
| Autor: | Vincenzo Gentile, Stefano Salciccia, Michele Innocenzi, Alessandro Sciarra, Alessandro Gentilucci, Susanna Cattarino |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Oncology medicine.medical_specialty medicine.drug_class medicine.medical_treatment 030232 urology & nephrology Urology MEDLINE Cochrane Library 03 medical and health sciences Prostate cancer 0302 clinical medicine Quality of life Internal medicine medicine Humans Biochemical progression Prostatectomy business.industry Prostatic Neoplasms Androgen Antagonists Hematology Androgen medicine.disease Biochemical failure Intermittent androgen deprivation therapy Radical prostatectomy Radiotherapy Geriatrics and Gerontology Radiation therapy 030220 oncology & carcinogenesis Disease Progression Quality of Life Neoplasm Recurrence Local business |
| Zdroj: | Critical Reviews in Oncology/Hematology. 99:351-361 |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2016.01.008 |
| Popis: | Purpose To evaluate clinical data from published trials on the use of intermittent androgen deprivation (IAD) therapy in patients with biochemical relapse after radical prostatectomy (RP). Methods We searched the Medline and Cochrane Library databases for literature published on IAD and biochemical progression after radical prostatectomy. Results To date, we have oncological and functional data from phase 3 studies focused on metastatic and locally advanced stages that confirmed IAD as a valid option treatment. For the aim of this review, only Tunn study, was specifically focused on patients who relapsed after surgery but clear and mature results are still missed. Conclusions The use of IAD in cases who relapse after RP is common in the clinical practice. Although specific recommendation on the use of IAD in this setting of patients are not available, we concluded that the real benefit of IAD in terms of long survival and quality of life is mainly for patients treated with surgery. |
| Databáze: | OpenAIRE |
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