Application of patient population-derived pharmacokinetic-pharmacodynamic relationships to tigecycline breakpoint determination for staphylococci and streptococci
| Autor: | Paul G. Ambrose, Brenda Cirincione, Sujata M. Bhavnani, Julie A. Passarell, Scott A. Van Wart, Alison K. Meagher, Evelyn J. Ellis-Grosse |
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| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Staphylococcus aureus Micrococcaceae medicine.drug_class Antibiotics Minocycline Tigecycline Microbial Sensitivity Tests medicine.disease_cause Gastroenterology Models Biological Microbiology Pharmacokinetics Internal medicine Streptococcal Infections medicine Humans Computer Simulation Antibacterial agent Models Statistical biology Streptococcus General Medicine Skin Diseases Bacterial biology.organism_classification Anti-Bacterial Agents Infectious Diseases ROC Curve Pharmacodynamics Area Under Curve Regression Analysis Staphylococcal Skin Infections Monte Carlo Method medicine.drug |
| Zdroj: | Diagnostic microbiology and infectious disease. 63(2) |
| ISSN: | 1879-0070 |
| Popis: | Correctly determined susceptibility breakpoints are important to both the individual patient and to society at large. A previously derived patient population pharmacokinetic model and Monte Carlo simulation (9999 patients) were used to create a likelihood distribution of tigecycline exposure, as measured by the area under the concentration-time curve at 24 h (AUC(24)). Each resultant AUC(24) value was paired with a clinically relevant fixed MIC value ranging from 0.12 to 2 mg/L. For each AUC(24)-MIC pair, the probability of microbiologic response was calculated using an exposure-response relationship, which was derived from patients with complicated skin and skin structure infections that involved Staphylococcus aureus or streptococci or both. The median probability of microbiologic success was 94% or greater for MIC values up to and including 0.25 mg/L. The median probability of microbiologic success was 66% or less for MIC values of 0.5 mg/L or greater. These data support a susceptibility breakpoint of 0.25 mg/L for S. aureus and streptococci. |
| Databáze: | OpenAIRE |
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