Systematic review and meta-analysis of the prevalence of neuropathic-like pain and/or pain sensitization in people with knee and hip osteoarthritis
| Autor: | Sultana Monira Hussain, Anita E. Wluka, Mahnuma M Estee, Joanne E. McKenzie, Luigi Zolio, Flavia M. Cicuttini, Mabel K. Yan, Kai Ying Lim |
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| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine medicine.medical_specialty Population Biomedical Engineering Osteoarthritis Osteoarthritis Hip 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine Prevalence medicine Humans Orthopedics and Sports Medicine education Sensitization 030203 arthritis & rheumatology Central Nervous System Sensitization education.field_of_study business.industry Osteoarthritis Knee medicine.disease Study heterogeneity 030104 developmental biology medicine.anatomical_structure Knee pain Meta-analysis Neuropathic pain Neuralgia Population study medicine.symptom business |
| Zdroj: | Osteoarthritis and Cartilage. 29:1096-1116 |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/j.joca.2021.03.021 |
| Popis: | Summary Objective To determine the prevalence of neuropathic-like pain (NP) and pain sensitization (PS) defined by self-report questionnaires in knee and hip osteoarthritis, and whether prevalence is potentially explained by disease-severity or affected joint. Design MEDLINE, EMBASE, CINAHL were systematically searched (1990–April 2020) for studies describing the prevalence of NP and PS in knee and hip osteoarthritis using self-report questionnaires. Random-effects meta-analysis was performed. Statistical heterogeneity between studies and sub-groups (affected joint and population source as a proxy for disease severity) was assessed (I2 statistic and the Chi-squared test). Results From 2,706 non-duplicated references, 39 studies were included (2011–2020). Thirty-six studies reported on knee pain and six on hip pain. For knee osteoarthritis, the pooled prevalence of NP was: using PainDETECT, possible NP(score ≥13) 40% (95%CI 32–48%); probable NP(score >18) 20% (95%CI 15–24%); using Self-Report Leeds Assessment of Neuropathic Symptoms and Signs, 32% (95%CI 26–38%); using Douleur Neuropathique (DN4) 41% (95% CI 24–59%). The prevalence of PS using Central Sensitization Inventory (CSI) was 36% (95% CI 12–59%). For hip osteoarthritis, the pooled prevalence of NP was: using PainDETECT, possible NP 29% (95%CI 22–37%%); probable NP 9% (95%CI 6–13%); using DN4 22% (95%CI 12–31%) in one study. The prevalence of possible NP pain was higher at the knee (40%) than the hip (29%) (difference 11% (95% CI 0–22%), P = 0.05). Conclusions Using self-report questionnaire tools, NP was more prevalent in knee than hip osteoarthritis. The prevalence of NP in knee and hip osteoarthritis were similar for each joint regardless of study population source or tool used. Whether defining NP using self-report questionnaires enables more effective targeted therapy in osteoarthritis requires investigation. |
| Databáze: | OpenAIRE |
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