Fungal nephrotoxins
| Autor: | P. K. C. Austwick |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Ochratoxin A
Aflatoxin Swine Food Contamination Biology Kidney Microbiology Nephrotoxicity chemistry.chemical_compound Penicillic acid Viridicatumtoxin B Animals Mycotoxin Swine Diseases General Veterinary Penicillium food and beverages General Medicine Mycotoxins Animal Feed Citrinin Aspergillus Kidney Tubules chemistry Animals Domestic Food Microbiology Kidney Diseases Balkan Nephropathy |
| Zdroj: | Veterinary Research Communications. 7:145-154 |
| ISSN: | 1573-7446 0165-7380 |
| DOI: | 10.1007/bf02228610 |
| Popis: | The nature, occurrence and effects of nephrotoxic mycotoxins are considered at their different levels of involvement in animal renal disease. The four associated with field outbreaks of nephrotoxicosis, viz. ochratoxin A, citrinin, aflatoxin and oxalic acid are mainly produced by Aspergilli and Penicillia in grain and other crops, e.g. peanuts. Ten nephrotoxins detected by experimentation including cyclopiazonic acid, penicillic acid and viridicatumtoxin, may also eventually be found to play a role in these diseases. Thirteen fungi frequently isolated from foodstuffs have produced renal (mostly tubular) lesions on the feeding of cultures to animals, in the absence of known nephrotoxins. The pathological changes reported have been predominantly in the proximal tubules with profound cytoplasmic and nuclear effects. The relationship of porcine nephropathy (due to ochratoxin A) to Balkan Nephropathy and the associated urinary tract tumours in man is discussed and the close parallel to the carcinogenic hepatoxicity of the aflatoxins indicated. |
| Databáze: | OpenAIRE |
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