Effect of mode of incorporation of disintegrants on the characteristics of fluid-bed wet-granulated tablets
| Autor: | Adel Sakr, Ibrahim Khattab, Anil G. Menon |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pharmacology
Croscarmellose sodium Chromatography Chemistry Surface Properties Chemistry Pharmaceutical Pharmaceutical Science Excipients Factorial experimental design chemistry.chemical_compound Granulation Pharmaceutical technology Drug Stability Fluidized bed Hardness Sodium Starch Glycolate Regression Analysis Dissolution Percent release Acetaminophen Tablets |
| Zdroj: | The Journal of pharmacy and pharmacology. 45(8) |
| ISSN: | 0022-3573 |
| Popis: | A full factorial experimental design was employed to investigate the effects of mode of disintegrant incorporation and concentration in wet-granulated paracetamol tablets manufactured by topspray fluid-bed. Disintegrants (croscarmellose sodium, sodium starch glycolate, or crospovidone) were incorporated either intragranularly, extragranularly, or distributed equally between the two phases. The results were analysed by a general quadratic equation and response surfaces generated. On examining the results for dissolution studies the combined mode resulted in significantly faster dissolution rates than did the extragranular mode which, in turn, was superior to the intragranular mode of inclusion. These results were reflected in the disintegration studies where the combined mode exhibited the shortest disintegration times for all the disintegrants. Tablet crushing strength was not affected by the mode of incorporation of concentration of the disintegrants. Main as well as interaction effects between the types, mode of incorporation and percent disintegrant employed were significant (P < 0·05) for disintegration time and percent release at 15 min. Croscarmellose sodium exhibited the shortest while crospovidone displayed significantly (P < 0·05) longer disintegration times. Formulations containing crospovidone did not meet official compendial (USP XXII) requirements of 80% in 30 min. In general, croscarmellose sodium and sodium starch glycolate were found to be less sensitive to the mode of incorporation than crospovidone. |
| Databáze: | OpenAIRE |
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