Echogenicity of Dupuytren's nodules is correlated to myofibroblast load and nodule hardness
| Autor: | Paul M N Werker, Whangzao Song, Sanne Molenkamp, Dieuwke C Broekstra, Marjolein Bloembergen |
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| Přispěvatelé: | Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Life Course Epidemiology (LCE) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pathology
medicine.medical_specialty myofibroblasts Negative association DISEASE Hardness Dupuytren's contracture Humans Medicine tonometry business.industry Histopathological analysis Ultrasound Echogenicity Nodule (medicine) ultrasonography medicine.disease PREVALENCE Dupuytren Contracture CONTRACTURE Surgery medicine.symptom Ultrasonography business Myofibroblast |
| Zdroj: | Journal of Hand Surgery (European volume), 47(3), 280-287. SAGE Publications Inc. |
| ISSN: | 1753-1934 |
| Popis: | This study aimed to determine the association between the echogenicity of Dupuytren’s disease nodules and myofibroblast load, and between echogenicity and nodule hardness. Thirty-eight nodules were assessed sonographically. The echogenicity of nodules was measured objectively with Image J (grey-value) and subjectively by visual inspection (hypo-, mixed and hyper-echogenicity). These findings were compared with myofibroblast load measured by histopathological analysis. In a different cohort, 97 nodules were assessed for grey-value and nodule hardness using a tonometer. There was a moderate, significant, negative association between grey-value and myofibroblast load and the subjective visual measurements corresponded to this finding. There was also a moderate, significant, negative association between grey-value and nodule hardness. Ultrasound and tonometry may be useful in the selection of patients for possible future preventive treatments. |
| Databáze: | OpenAIRE |
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