Host-related factors for venous thromboembolism following total joint replacement: A meta-analysis of 89 observational studies involving over 14 million hip and knee replacements
| Autor: | Ashley W Blom, Setor K Kunutsor, Michael R Whitehouse, Matthew C. Barrett |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Arthroplasty Replacement Hip medicine.medical_treatment MEDLINE Knee replacement Cochrane Library 03 medical and health sciences Postoperative Complications 0302 clinical medicine Risk Factors Internal medicine medicine Humans Orthopedics and Sports Medicine Elective surgery Arthroplasty Replacement Knee 030222 orthopedics Anthropometry business.industry Venous Thromboembolism Arthroplasty Observational Studies as Topic Centre for Surgical Research Relative risk Meta-analysis Surgery business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Kunutsor, S, Barrett, M, Blom, A & Whitehouse, M 2019, ' Host-related factors for venous thromboembolism following total joint replacement : A meta-analysis of 89 observational studies involving over 14 million hip and knee replacements ', Journal of Orthopaedic Science . https://doi.org/10.1016/j.jos.2019.04.003 |
| ISSN: | 0949-2658 |
| DOI: | 10.1016/j.jos.2019.04.003 |
| Popis: | BACKGROUND: Venous thromboembolism, a potential complication of total joint replacement, is associated with preventable mortality and morbidity and is likely to be influenced by host-related factors such as sociodemographic characteristics, body mass index, medical and surgical histories, as well as circulating biomarkers. We conducted a systematic review and meta-analysis to assess the associations between host-related factors and venous thromboembolism risk following total hip and knee replacements.METHODS: We searched MEDLINE, Embase, Web of Science, and Cochrane Library to March 2018 for longitudinal studies reporting these associations. Summary measures of association were relative risks (95% confidence intervals).RESULTS: We identified 89 studies with data on 14,763,963 joint replacements and 150,086 venous thromboembolism events. Comparing males to females, age ≥70 to CONCLUSIONS: Enhanced venous thromboembolism prophylaxis should be considered in those with nonmodifiable risk factors such as older black female knee replacement patients. Modifiable risk factors such as high body mass index and fluid & electrolyte imbalance should be addressed prior to elective surgery.SYSTEMATIC REVIEW REGISTRATION: PROSPERO 2018: CRD42018089625. |
| Databáze: | OpenAIRE |
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