Endoscopic Ultrasound Features of Multiple Endocrine Neoplasia Type 1-Related versus Sporadic Pancreatic Neuroendocrine Tumors: A Single-Center Retrospective Study
| Autor: | Alberto Caimo, Simona R Bergmann, Peter H. Kann, Vanessa Scherer, Gianluca Tamagno |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Endoscopic ultrasound medicine.medical_specialty Biostatistics Neuroendocrine tumors Single Center Endosonography Lesion Young Adult 03 medical and health sciences 0302 clinical medicine Medicine and Health Sciences Multiple Endocrine Neoplasia Type 1 medicine Humans Multiple endocrine neoplasia Pancreas Aged Retrospective Studies endoscopy Sporadic Pancreatic Neuroendocrine Tumors medicine.diagnostic_test business.industry Gastroenterology Retrospective cohort study Middle Aged medicine.disease Endoscopy Pancreatic Neoplasms Neuroendocrine Tumors medicine.anatomical_structure 030220 oncology & carcinogenesis Feasibility Studies 030211 gastroenterology & hepatology Radiology medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Articles |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000487939 |
| Popis: | Aim: Pancreatic neuroendocrine tumors (pNETs) can occur in patients with a familial syndrome either as multiple endocrine neoplasia type 1 (MEN-1) or as sporadic tumors. Endoscopic ultrasound (EUS) has become one of the first-line investigations for pNET characterization. The ultrasonographic features of pNETs may differ depending on the familial versus sporadic pathogenesis of the tumor. Therefore, the EUS findings could help and direct the definition of a pNET with an impact on the most appropriate diagnostic and therapeutic patient management. Methods: In this single-center retrospective study, we reviewed the EUS features of 94 pNETs from 37 MEN-1 patients and 15 pNETs from 11 sporadic disease patients at the time of their first EUS assessment. We analyzed the most relevant morphological and ultrasonographic characteristics of the tumors and compared the findings between the 2 patient groups. Results: Patients with MEN-1 more likely present with multiple pNETs than patients with sporadic disease. Sporadic pNETs are usually much bigger than those due to MEN-1. Moreover, pNETs are more heterogeneous in patients with sporadic disease than in those with MEN-1. No statistical difference with regard to definition of the margins, morphology, and vascularization of the pNETs appears between the 2 groups. Conclusions: Patients with sporadic disease usually present with bigger and more heterogeneous pNETs than patients with MEN-1, who tend to present with a higher number of lesions. EUS can facilitate the precise characterization of a pNET, and the ultrasonographic features of the lesion can help and distinguish MEN-1-related versus sporadic disease. |
| Databáze: | OpenAIRE |
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