Implication of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Interleukin-3 (IL-3) in Children with Acute Myeloid Leukaemia (AML)
| Autor: | Osama Elbaz, Ali Shaltout |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
business.industry
Significant difference Endogeny Hematology Colony-stimulating factor Granulopoiesis Pathogenesis 03 medical and health sciences 0302 clinical medicine Granulocyte macrophage colony-stimulating factor hemic and lymphatic diseases 030220 oncology & carcinogenesis Immunology medicine Myeloid leukaemia business 030215 immunology medicine.drug Interleukin 3 |
| Zdroj: | Hematology (Amsterdam, Netherlands). 5(5) |
| ISSN: | 1024-5332 |
| Popis: | Granulocyte-macrophage colony stimulating factor (GM-CSF) and Interleukin-3 (IL-3) are increasingly used to stimulate granulopoiesis in neutropenic patients but these are rarely used in the lights of knowledge of the endogenous CSF-levels. In this study we measured serum levels of GM-CSF and IL-3 at diagnosis and after remission in children with acute leukaemia, using an enzyme linked immuno-sorbent assay (ELISA) techniques in 14 patients with acute myeloid leukaemia (AML) and 27 patients with acute lymphoblastic leukaemia (ALL). Twelve healthy age-matched children were used as a reference group. AML patients showed a highly significant increase in serum levels of GM-CSF and IL-3 before induction of therapy (p0.0001) compared to the reference control group, with a highly significant decline of both GM-CSF and IL-3 (p0.0001) after successful remission. On the other hand, ALL patients showed no significant elevation of GM-CSF and IL-3 at diagnosis (p0.5), with no significant difference between preinduction and postinduction serum levels of either (p0.5). Since these cytokines are known to be fundamental for the growth of AML cells, we postulate that the pretreatment levels of both GM-CSF and IL-3 could play a role in the pathogenesis of AML. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|