Is there a link between insulin resistance and inflammatory activation in preeclampsia?
| Autor: | Thomas W. Rademacher, Pantaleo Greco, M. Scioscia, Luigi Selvaggi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Biology Carbohydrate metabolism Systemic inflammation NO Preeclampsia chemistry.chemical_compound Insulin resistance Pre-Eclampsia Pregnancy Internal medicine medicine Humans Inositol Severe complication Inflammation Insulin General Medicine medicine.disease Endocrinology chemistry Immunology Female Insulin Resistance medicine.symptom |
| Zdroj: | Medical Hypotheses. 73:813-817 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2009.01.057 |
| Popis: | Preeclampsia is a severe complication of human pregnancy and an insulin resistant state has been demonstrated in this multisystem disorder, although its bases remain unclear. Inositol phosphoglycans P-type belongs to a family of putative insulin mediators and was described to exert many insulin-like effects on lipid and glucose metabolism. A definite association between this molecule and preeclampsia was reported. The systemic inflammatory activation that occurs in preeclampsia as a consequence of the immunological dysfunction can exacerbate placental insulin resistance leading to an over-expression of P-IPG as a counterregulatory mechanism to insulin resistance. Besides, the lipidic form of P-IPG was reported to be similar to endotoxins, and may represent the link between insulin resistance, systemic inflammation and increased angiogenic factors. In this article we propose a new working theory on insulin resistance and preeclampsia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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