A subset of low-grade B cell lymphomas with a follicular growth pattern but without a BCL2 translocation shows features suggestive of nodal marginal zone lymphoma
| Autor: | Patricia H. J. van Cleef, Konnie M. Hebeda, Michiel van den Brand, Olga Balagué, J. Han van Krieken, Daphne de Jong, Patricia J. T. A. Groenen |
|---|---|
| Přispěvatelé: | Pathology, CCA - Cancer biology |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty BCL2 Histology Nodal marginal zone lymphoma Chemistry(all) Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] Follicular lymphoma Energy Engineering and Power Technology Chromosomal translocation Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] Biology Physics and Astronomy(all) Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine immune system diseases Internal medicine hemic and lymphatic diseases Follicular phase medicine Low grade B-cell lymphoma Low-grade B cell lymphoma neoplasms B cell Hematology medicine.disease Pollution medicine.anatomical_structure Fuel Technology 030220 oncology & carcinogenesis Chemical Engineering(all) Original Article 030215 immunology |
| Zdroj: | Journal of Hematopathology van den Brand, M, Balague, O, van Cleef, P H J, Groenen, P J T A, Hebeda, K M, de Jong, D & van Krieken, J H J M 2016, ' A subset of low-grade B cell lymphomas with a follicular growth pattern but without a BCL2 translocation shows features suggestive of nodal marginal zone lymphoma ', JOURNAL OF HEMATOPATHOLOGY, vol. 9, no. 1, pp. 3-8 . https://doi.org/10.1007/s12308-015-0259-y Journal of Hematopathology, 9, 3-8 JOURNAL OF HEMATOPATHOLOGY, 9(1), 3-8 Journal of Hematopathology, 9, 1, pp. 3-8 |
| ISSN: | 1865-5785 1868-9256 |
| DOI: | 10.1007/s12308-015-0259-y |
| Popis: | Contains fulltext : 166692.pdf (Publisher’s version ) (Open Access) In our consultation practice, it was noted that many cases that were considered to represent follicular lymphoma (FL) without a BCL2 translocation were ultimately classified as nodal marginal zone lymphoma (NMZL). This study set out to define recurrent morphological features of these cases. Thirty-three low-grade B cell lymphomas without a BCL2 rearrangement were studied for recurrent morphological features. These features were then applied on 20 randomly selected cases to verify if these criteria are able to distinguish between lymphomas with and without a BCL2 rearrangement, assigning them to one of five categories ranging from "certain FL" to "certain NMZL." Highly recurrent morphological features were noted in the lymphomas without a BCL2 rearrangement, which were strongly overlapping with the morphological features of NMZL. All six cases that were assigned to the category of certainly FL or most likely FL indeed harbored a BCL2 rearrangement, whereas all 12 cases assigned to the category of most likely NMZL or certain NMZL had no BCL2 break. Of the two cases in the ambiguous category, one had received a final diagnosis of FL and the other of NMZL. This study raises the hypothesis that a subset of low-grade B cell lymphomas with a follicular growth pattern but without a BCL2 translocation actually represents NMZL. This is at present difficult to prove, because no gold standard is available to differentiate between NMZL and FL without a BCL2 rearrangement, so further investigations are needed. |
| Databáze: | OpenAIRE |
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