Lymphomatoid Granulomatosis in a 14-Year-Old Boy with Trisomy 21 and History of B-Lymphoblastic Leukemia/Lymphoma
| Autor: | Anna P. Matynia, Sherrie L. Perkins, David Li |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Lymphomatoid granulomatosis Adolescent medicine.medical_treatment Pathology and Forensic Medicine 03 medical and health sciences Immunocompromised Host 0302 clinical medicine Fatal Outcome Maintenance therapy 030225 pediatrics Antineoplastic Combined Chemotherapy Protocols medicine Humans Immunodeficiency Lung business.industry Immunosuppression Lymphomatoid Granulomatosis Neoplasms Second Primary General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Dermatology Lymphoma Leukemia Pneumonia medicine.anatomical_structure 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Down Syndrome business |
| Zdroj: | Fetal and pediatric pathology. 37(1) |
| ISSN: | 1551-3823 |
| Popis: | Background: Lymphomatoid granulomatosis is a EBV-driven lymphoproliferative disorder that has been reported in association with immunodeficiency, but only exceptionally in patients with hematopoietic malignancy. Case report: A 14-year-old boy with trisomy-21 and a history of B-lymphoblastic leukemia/lymphoma (B-ALL) diagnosed 1.5 years prior, on maintenance chemotherapy, presented with fever and respiratory symptoms. Chest X-ray revealed right-lower-lobe consolidation. He was treated for pneumonia but continued to be febrile with worsening respiratory status, with development of additional pulmonary and liver nodules. No infectious etiology was identified. Following nondiagnostic lung and liver biopsies, the largest pulmonary mass was resected. The histopathologic findings were diagnostic of lymphomatoid granulomatosis. There was no residual B-ALL. The patient's status continued to deteriorate and he died shortly thereafter. Conclusion: Relative immunosuppression due to maintenance therapy for B-A... |
| Databáze: | OpenAIRE |
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