Habropetaline A, an antimalarial naphthylisoquinoline alkaloid from Triphyophyllum peltatum
| Autor: | Gerhard Bringmann, Babett Schwöbel, Reto Brun, Kim Messer, Laurent Aké Assi |
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| Rok vydání: | 2003 |
| Předmět: |
Erythrocytes
Stereochemistry medicine.drug_class Plasmodium falciparum Molecular Conformation Leishmania donovani Naphthols Plant Science Naphthalenes Horticulture Trypanosoma brucei Pharmacognosy Biochemistry Antimalarials Alkaloids parasitic diseases medicine Animals Humans Nuclear Magnetic Resonance Biomolecular Molecular Biology Plants Medicinal biology Alkaloid General Medicine Isoquinolines biology.organism_classification Dioncophyllaceae Triphyophyllum Antiprotozoal |
| Zdroj: | Phytochemistry. 62:345-349 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/s0031-9422(02)00547-2 |
| Popis: | The isolation, structural elucidation, and antiprotozoal activities of habropetaline A, a novel naphthylisoquinoline alkaloid from Triphyophyllum peltatum , are described. This alkaloid had previously only been identified on line, by the LC–MS/MS–NMR–CD triad, in the crude extract of the rare and difficult-to-provide related plant species Habropetalum dawei , whose small quantities available had not permitted to isolate the compound. As predicted by quantitative structure–activity relationship (QSAR) investigations, habropetaline A exhibits strong antimalarial activity against Plasmodium falciparum , while it is inactive against other protozoal pathogens ( Trypanosoma brucei rhodesience , T. cruzi , and Leishmania donovani ). |
| Databáze: | OpenAIRE |
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