Psychobiotics Regulate the Anxiety Symptoms in Carriers of Allele A of IL-1β Gene: A Randomized, Placebo-Controlled Clinical Trial

Autor:	Gualtieri P 1, Marchetti M 1, 2, Cioccoloni G 3, De Lorenzo A 1, 4, Romano L 1, Cammarano A 5, Colica C 4, 6, Condò R 7, Di Renzo L 1.
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine medicine.medical_specialty Hamilton Anxiety Rating Scale Article Subject Immunology Placebo Settore MED/49 law.invention 03 medical and health sciences Probiotic 0302 clinical medicine law Internal medicine medicine Pathology RB1-214 Risk factor business.industry Cell Biology medicine.disease Clinical trial 030104 developmental biology Mood Mood disorders Anxiety medicine.symptom business 030217 neurology & neurosurgery
Zdroj:	Mediators of Inflammation, Vol 2020 (2020) Mediators of inflammation (Online) 2020 (2020): 2346126. doi:10.1155/2020/2346126 info:cnr-pdr/source/autori:Gualtieri P 1, Marchetti M 1,2, Cioccoloni G 3, De Lorenzo A 1,4, Romano L 1,2, Cammarano A 5, Colica C 4,6, Condò R 7, Di Renzo L 1./titolo:Psychobiotics Regulate the Anxiety Symptoms in Carriers of Allele A of IL-1? Gene: A Randomized, Placebo-Controlled Clinical Trial./doi:10.1155%2F2020%2F2346126/rivista:Mediators of inflammation (Online)/anno:2020/pagina_da:2346126/pagina_a:/intervallo_pagine:2346126/volume:2020
ISSN:	0962-9351
DOI:	10.1155/2020/2346126
Popis:	Background. Probiotic oral intake, via modulation of the microbiota-gut-brain axis, can impact brain activity, mood, and behavior; therefore, it may be beneficial against psychological distress and anxiety disorders. Inflammatory cytokines can influence the onset and progression of several neurodegenerative mood disorders, and the IL-1βrs16944 SNP is related to high cytokine levels and potentially affects mood disorders. The aim of this study was to examine the combined effect of IL-1βpolymorphism and probiotic administration in mood disorder phenotypes in the Italian population.Methods. 150 subjects were randomized into two different groups, probiotic oral suspension group (POSG) and placebo control group (PCG), and received the relative treatment for 12 weeks. Psychological profile assessment by Hamilton Anxiety Rating Scale (HAM-A), Body Uneasiness Test (BUT), and Symptom Checklist 90-Revised (SCL90R) was administered to all volunteers. Genotyping was performed on DNA extracted from salivary samples.Results. After 12 weeks of intervention, a significant reduction of HAM-A total score was detected in the POSG (p<0.01), compared to the PCG. Furthermore, IL-1βcarriers have moderate risk to develop anxiety (OR=5.90), and in POSG IL-1βcarriers, we observed a reduction of HAM-A score (p=0.02).Conclusions. Consumption of probiotics mitigates anxiety symptoms, especially in healthy adults with the minor A allele of rs16944 as a risk factor. Our results encourage the use of probiotics in anxiety disorders and suggest genetic association studies for psychobiotic-personalized therapy.
Databáze:	OpenAIRE
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