Diffusion-weighted MR imaging of the liver of hepatitis C patients
| Autor: | Bich N. Nguyen, Mourad Amara, Luigi Lepanto, Viviane Nicolet, Yvan Boulanger, Guy Allaire, Marc Poliquin, Gilles Beaudoin |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Liver Cirrhosis Male Sensitivity and Specificity Fibrosis medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Diffusion-Weighted MR Imaging Spectroscopy Hepatitis c viral medicine.diagnostic_test business.industry Reproducibility of Results Magnetic resonance imaging Hepatitis C Control subjects medicine.disease Diffusion Magnetic Resonance Imaging Liver Molecular Medicine Female business Nuclear medicine Diffusion MRI |
| Zdroj: | NMR in biomedicine. 16(3) |
| ISSN: | 0952-3480 |
| Popis: | Magnetic resonance diffusion-weighted imaging (DWI) of the liver was investigated to determine whether this method could be used to differentiate between the stages of fibrosis and inflammation for hepatitis C viral infection. DWI data were recorded for 18 hepatitis C patients and 10 control subjects using a modified pulse sequence allowing a 52 ms echo time delay. Acquisitions were performed with breath holding using five different b gradient factor values ranging between 50 and 250 s/mm(2) and in the three axes. Apparent diffusion coefficient (ADC) values were measured from a 5.7 cm(2) area in the central region of the liver. The inflammation and fibrosis grades were evaluated histologically on a biopsy sample. The mean ADC values were 2.30 +/- 1.28 x 10(-3) and 1.79 +/- 0.25 x 10(-3) mm(2)/s for hepatitis C patients and control subjects, respectively. Using our technique, no correlation could be found between the ADC values and the inflammation or fibrosis scores, indicating that tissue changes produced by hepatitis C do not appear to be quantifiable by DWI. |
| Databáze: | OpenAIRE |
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