Upregulated expression of long noncoding RNA SNHG15 promotes cell proliferation and invasion through regulates MMP2/MMP9 in patients with GC

Autor: Zhen Zheng, Hua-fang Su, Zhenghua Fei, Jun-Feng Yin, Su-Xiu Chen, Congying Xie, Baochai Lin
Rok vydání: 2015
Předmět:
0301 basic medicine
Male
Pathology
MMP2
Apoptosis
Kaplan-Meier Estimate
MMP9
medicine.disease_cause
Mice
0302 clinical medicine
Cell Movement
Neoplasm Metastasis
Gene knockdown
General Medicine
Middle Aged
Prognosis
Long non-coding RNA
Tumor Burden
Up-Regulation
Gene Expression Regulation
Neoplastic
Cell Transformation
Neoplastic
Matrix Metalloproteinase 9
030220 oncology & carcinogenesis
Matrix Metalloproteinase 2
Female
RNA
Long Noncoding
Adult
medicine.medical_specialty
Biology
03 medical and health sciences
Stomach Neoplasms
Cell Line
Tumor
medicine
Biomarkers
Tumor
Animals
Humans
Aged
Cell Proliferation
Neoplasm Staging
Cell growth
Gene Expression Profiling
Cancer
medicine.disease
Xenograft Model Antitumor Assays
Disease Models
Animal
030104 developmental biology
ROC Curve
Cancer research
Ectopic expression
Neoplasm Grading
Carcinogenesis
Follow-Up Studies
Zdroj: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(5)
ISSN: 1423-0380
Popis: Accumulation of data indicates that misregulated long noncoding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression and might be served as diagnosis and prognosis biomarker or potential therapeutic targets. Identification of cancer-associated lncRNAs and investigation of their biological functions and molecular mechanisms are significant for understanding the development and progression of cancer. In this study, we identified a novel lncRNA SNHG15, whose expression was upregulated in tumor tissues in 106 patients with gastric cancer (GC) compared with those in the adjacent normal tissues (P
Databáze: OpenAIRE
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