Improving the Yield of Blood Cultures from Patients with Early Lyme Disease
| Autor: | Denise Cooper, Gary P. Wormser, Dionysios Liveris, Radha Iyer, Mary E. Cox, Susan Bittker, Ira Schwartz |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Microbiology (medical) Polymerase Chain Reaction Sensitivity and Specificity Lyme disease medicine Humans Blood culture Borrelia burgdorferi Aged Whole blood Aged 80 and over Bacteriological Techniques Lyme Disease biology medicine.diagnostic_test business.industry Bacteriology Middle Aged biology.organism_classification medicine.disease United States Blood Bacteremia Immunology Erythema chronicum migrans Lyme disease microbiology Erythema migrans Female medicine.symptom business |
| Zdroj: | Journal of Clinical Microbiology. 49:2166-2168 |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.00350-11 |
| Popis: | Approximately 45% of untreated United States patients with early Lyme disease associated with erythema migrans have a positive blood culture based on microscopic detection of Borrelia burgdorferi in Barbour-Stoenner-Kelly medium after 2 to 12 weeks of incubation. In this study we demonstrate that the yield of blood cultures can be significantly increased to 70.8% by the use of a combined culture-quantitative PCR technique and that among those patients found to have a positive blood culture, positivity was detected in over 90% within just 7 days of incubation. Patients with multiple erythema migrans were almost uniformly culture positive by this technique. |
| Databáze: | OpenAIRE |
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