Long COVID in Patients With Mild to Moderate Disease: Do Thyroid Function and Autoimmunity Play a Role?
| Autor: | David T W Lui, Anthony Raymond Tam, Wing Sun Chow, Kelvin K. W. To, Eunice Ka Hong Leung, Kathryn C.B. Tan, Chi Ho Lee, Ching-Wan Lam, Ivan Hung, Tip Yin Ho, Carol H.Y. Fong, Yu Cho Woo, Chun Yiu Law, Polly Pang, Karen S.L. Lam, Alan Chun Hong Lee |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty autoantibodies Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyroid Gland Thyroid function tests Gastroenterology Endocrinology Thyroid-stimulating hormone Thyroid peroxidase Interquartile range Internal medicine medicine Humans biology medicine.diagnostic_test SARS-CoV-2 thyroid function tests business.industry autoimmunity COVID-19 General Medicine Odds ratio Middle Aged post-acute COVID-19 syndrome Thyroid disorder biology.protein Female Original Article Thyroglobulin Thyroid function business |
| Zdroj: | Endocrine Practice |
| ISSN: | 1530-891X |
| Popis: | Objective Long COVID (LC) is an emerging global health issue. Fatigue is a common feature. Whether thyroid function and autoimmunity play a role is uncertain. We aimed to evaluate the prevalence and predictors of LC and the potential role of thyroid function and autoimmunity in LC. Methods We included consecutive adults without known thyroid disorder, admitted to a major COVID-19 centre for confirmed COVID-19 from July to December 2020 who had thyroid function tests (TFTs) and anti-thyroid antibodies measured on admission and at follow-up. LC was defined by the presence or persistence of symptoms upon follow-up. Results In total, 204 patients (median age: 55.0 years; 46.6% men) were reassessed at a median of 89 days (IQR: 69–99) after acute COVID-19. Forty-one (20.1%) had LC. Female (adjusted odds ratio [aOR] 2.48, p=0.018) and SARS-CoV-2 PCR cycle threshold value Long COVID is common among COVID-19 survivors, with female and those with higher viral load in acute COVID-19 particularly vulnerable. Our observation of incident anti-TPO positivity among COVID-19 survivors warrants further follow-up for thyroid dysfunction. Whether anti-TPO plays a protective role in long COVID remains to be elucidated. |
| Databáze: | OpenAIRE |
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