Ovarian activity in women taking an oral contraceptive containing 20 microg ethinyl estradiol and 150 microg desogestrel: effects of low estrogen doses during the hormone-free interval
| Autor: | Ann Jeanette Davis, S. R. Killick, C. Fitzgerald |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.drug_class Placebo Ethinyl Estradiol Drug Administration Schedule Follicle Double-Blind Method Ovarian Follicle Desogestrel Reference Values Internal medicine Follicular phase medicine Humans Vaginal bleeding Menstrual Cycle Progesterone Ultrasonography Dose-Response Relationship Drug Estradiol business.industry Obstetrics and Gynecology Contraceptives Oral Combined Drug Combinations Endocrinology Estrogen Female Folliculogenesis medicine.symptom business hormones hormone substitutes and hormone antagonists Hormone medicine.drug |
| Zdroj: | American journal of obstetrics and gynecology. 179(1) |
| ISSN: | 0002-9378 |
| Popis: | OBJECTIVE: We assessed the effect of low ethinyl estradiol doses given during the nominally hormone-free interval of the Mircette™ (brand of desogestrel/ethinyl estradiol and ethinyl estradiol) contraceptive regimen on ovarian activity. STUDY DESIGN: In a randomized, double-blind study, healthy women received 150 μg desogestrel and 20 μg ethinyl estradiol for 21 days followed by either placebo for 7 days (Mircette™/placebo; N = 24) or placebo for 2 days and 10 μg ethinyl estradiol for 5 days (Mircette™/ethinyl estradiol; N = 23). RESULTS: During cycles 2 and 3, the Mircette™/placebo group had a higher incidence of persistent ovarian follicles (eight subjects versus three subjects) and on average a greater maximum follicle diameter than the Mircette™/ethinyl estradiol group. One Mircette™/placebo subject probably ovulated in cycle 2, and another had a luteinized unruptured follicle; no such activity was seen in the in the Mircette™/ethinyl estradiol group. The study medication was well tolerated, and there were no apparent between-group differences in vaginal bleeding patterns. CONCLUSION: The Mircette™ regimen, which includes low ethinyl estradiol doses during the hormone-free interval, more effectively suppresses ovarian follicular activity with a low monthly estrogen dose. |
| Databáze: | OpenAIRE |
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