Improved Aedes aegypti mosquito reference genome assembly enables biological discovery and vector control
| Autor: | Hugh M. Robertson, Jill Muehling, Frederick A. Partridge, Sanjit S. Batra, Joe Turner, Noah H. Rose, William C. Black, Aviva Presser Aiden, Michael R. Murphy, Catherine A. Hill, Jacob E. Crawford, Alistair C. Darby, Erez Lieberman Aiden, Daniel E. Neafsey, Adam M. Phillippy, William J. Glassford, Alexander S. Raikhel, Richard Hall, Melissa Smith, Vinita Joardar, Louis Lambrechts, Andrew K. Jones, Margaret Herre, Paul Peluso, Allison M Weakley, Joyce Lee, Han Cao, Eric Cox, Seth Redmond, Yang Wu, Terence Murphy, Raissa G.G. Kay, Igor Filipović, Maria V. Sharakhova, Vamsi K. Kodali, Carolyn S. McBride, Karla Saavedra-Rodriguez, Shruti Sharan, Gordana Rašić, Zhijian Tu, Albin Fontaine, Gareth D. Weedall, Igor V. Sharakhov, Sarah B. Kingan, Bradley J. White, J. Spencer Johnston, Thanyalak Fansiri, Olga Dudchenko, Richard S. Mann, Jonas Korlach, Steven D. Buckingham, Omar S. Akbari, David B. Sattelle, Saki Chan, Sara N. Mitchell, Corey L. Campbell, Benjamin J. Matthews, Atashi Sharma, Li Zhao, Gareth J Lycett, Benjamin R. Evans, Jeffrey R. Powell, Sergey Koren, Andrea Gloria-Soria, Leslie B. Vosshall, Igor Antoshechkin, Arina D. Omer, Zhilei Zhao, Vidya Ramasamy, Sourav Roy, Alex Hastie, Carlos A Brito-Sierra |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
education.field_of_study Population Yellow fever Genomics Aedes aegypti Computational biology Biology biology.organism_classification medicine.disease_cause medicine.disease Genome Dengue fever 03 medical and health sciences 030104 developmental biology medicine Chikungunya education Reference genome |
| Zdroj: | Nature |
| Popis: | Female Aedes aegypti mosquitoes infect hundreds of millions of people each year with dangerous viral pathogens including dengue, yellow fever, Zika, and chikungunya. Progress in understanding the biology of this insect, and developing tools to fight it, has been slowed by the lack of a high-quality genome assembly. Here we combine diverse genome technologies to produce AaegL5, a dramatically improved and annotated assembly, and demonstrate how it accelerates mosquito science and control. We anchored the physical and cytogenetic maps, resolved the size and composition of the elusive sex-determining “M locus”, significantly increased the known members of the glutathione-S-transferase genes important for insecticide resistance, and doubled the number of chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites. Using high-resolution QTL and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. We predict that AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly arboviral vector. |
| Databáze: | OpenAIRE |
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