Elastography and Metalloproteinases in Patients at High Risk of Preterm Labor
| Autor: | Izabela Dymanowska-Dyjak, Tomasz Gęca, Adrianna Kondracka, Aleksandra Stupak, Arkadiusz Krzyżanowski, Anna Kwaśniewska |
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| Rok vydání: | 2021 |
| Předmět: |
preterm labor
medicine.medical_specialty elastography Preterm labor macromolecular substances Matrix metalloproteinase high-risk patients environment and public health Article metalloproteinases mental disorders Medicine In patient Cervix Pregnancy Transvaginal ultrasonography medicine.diagnostic_test integumentary system business.industry Obstetrics ultrasound Ultrasound General Medicine medicine.disease medicine.anatomical_structure Elastography business MMP-9 MMP-8 |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 3886, p 3886 (2021) Volume 10 Issue 17 |
| ISSN: | 2077-0383 |
| Popis: | Preterm birth (PTB) is the leading cause of perinatal morbidity and mortality. Its etiopathology is multifactorial therefore, many of the tests contain the assessment of the biochemical factors and ultrasound evaluation of the cervix in patients at risk of preterm delivery. The study aimed at evaluating the socioeconomic data, ultrasound examinations with elastography, plasma concentrations of MMP-8 and MMP-9 metalloproteinases, and vaginal secretions in the control group as well as patients with threatened preterm delivery (high-risk patients). The study included 88 patients hospitalized in the Department of Obstetrics and Pregnancy Pathology, SPSK 1, in Lublin. Patients were qualified to the study group (50) with a transvaginal ultrasonography of cervical length (CL) ≤ 25 mm. The control group (38) were patients with a physiological course of pregnancy with CL > 25 mm. In the study group, the median length of the cervix was 17.49 mm. Elastographic parameters: strain and ratio were 0.20 and 0.83. In the control group, the median length of the cervix was 34.73 mm, while the strain and ratio were 0.20 and 1.23. In the study group, the concentration of MMP-8 in the serum and secretions of the cervix was on average 74.17 and 155.46 ng/mL, but in the control group, it was significantly lower, on average 58.49 and 94.19 ng/mL. The concentration of MMP-9 in both groups was on the same level. Evaluation of the cervical length and measurement of MMP-8 concentration are the methods of predicting preterm delivery in high-risk patients. The use of static elastography did not meet the criteria of a PTB marker. |
| Databáze: | OpenAIRE |
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