Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma
| Autor: | Koji Miyanishi, Kazuyuki Murase, Shintaro Sugita, Saki Ameda, Yohei Arihara, Kohichi Takada, Masaru Takagi, Takaaki Tsuchiya, Junji Kato, Joji Muramatsu, Keisuke Yamamoto, Koh-ichi Sakata |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Vincristine medicine.medical_specialty Cyclophosphamide Adolescent medicine.medical_treatment Ethmoid sinus Antineoplastic Combined Chemotherapy Protocols Internal Medicine medicine Carcinoma Humans Ifosfamide Etoposide Chemotherapy medicine.diagnostic_test business.industry Magnetic resonance imaging Nasopharyngeal Neoplasms General Medicine Chemoradiotherapy medicine.disease Radiation therapy medicine.anatomical_structure Radiology business medicine.drug |
| Zdroj: | Internal medicine (Tokyo, Japan). 61(8) |
| ISSN: | 1349-7235 |
| Popis: | An 18-year-old man presented with sudden vision loss in his left eye. Magnetic resonance imaging revealed a tumor that had invaded the left optic nerve, originating from the left posterior ethmoid sinus. Immunohistochemical analyses identified positive staining for NUT protein in the nuclei of tumor cells. We diagnosed locally advanced NUT carcinoma (NC) and initiated concurrent chemoradiotherapy (CCRT), consisting of chemotherapy with vincristine, doxorubicin, and cyclophosphamide, alternating with ifosphamide and etoposide, plus radiation therapy. The patient achieved a complete response. CCRT can be a useful treatment option for adolescent and young-adult patients with locally advanced unresectable NC. |
| Databáze: | OpenAIRE |
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