New insight and potential therapy for NAFLD: CYP2E1 and flavonoids
| Autor: | Lina Deng, Xiumei Gao, Lu Huang, Xiao Liu, Kaiyue Wang, Wangxiao Tan, Xiaoying Wang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
RM1-950 Bioinformatics Protective Agents digestive system Pathogenesis 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease NAFLD Nonalcoholic fatty liver disease medicine Effective treatment Animals Humans CYP2E1 Pathological Pharmacology Flavonoids Mechanism (biology) business.industry fungi NASH food and beverages nutritional and metabolic diseases Cytochrome P-450 CYP2E1 General Medicine medicine.disease digestive system diseases 030104 developmental biology NAFL 030220 oncology & carcinogenesis Therapeutics. Pharmacology business |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111326-(2021) |
| ISSN: | 1950-6007 |
| Popis: | Over the years, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased year by year; however, due to its complicated pathogenesis, there is no effective treatment so far. It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1. Therefore, flavonoids may become effective drugs for the treatment of NAFLD in the future. This prompted us to review the research progress of the pathological mechanism of NAFLD and the impact of CYP2E1 activity changes during the pathological process, and to summarize the protective effect of flavonoids against CYP2E1 activity. |
| Databáze: | OpenAIRE |
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