Increased irisin versus reduced fibroblast growth factor1 (FGF1) in relation to adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes
| Autor: | Violet Kasabri, Hana H. Abu-Hassan, Maysa Suyagh, Lana Halaseh, Mohammad Saleh, Ruba M. Jaber, Govand Yaseen Saber, Sundos AlAlawi |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Body adiposity index Prediabetic State 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetes mellitus Internal medicine Humans Medicine Prediabetes Molecular Biology Triglycerides Adiposity Metabolic Syndrome business.industry Cholesterol HDL Red blood cell distribution width General Medicine Middle Aged medicine.disease Fibronectins Fibroblast Growth Factor 1 Female Metabolic syndrome business Body mass index Biomarkers Lipid Accumulation Product |
| Zdroj: | Hormone Molecular Biology and Clinical Investigation. 38 |
| ISSN: | 1868-1891 1868-1883 2018-0063 |
| DOI: | 10.1515/hmbci-2018-0063 |
| Popis: | BackgroundIrisin and fibroblast growth factor 1 (FGF1) are intricately involved in metabolic syndrome (MetS) and prediabetes (preDM) pathophysiology. This study aimed to compare and correlate irisin and FGF1 plasma levels, adiposity, atherogenicity and hematological indices in 29 normoglycemic MetS and 30 newly diagnosed drug naive prediabetic (PreDM) MetS patients vs. 29 lean and normoglycemic controls.Materials and methodsIrisin and FGF1 plasma levels were measured using colorimetric assays. Intergroup comparisons were conducted by analysis of variance (ANOVA). Spearman’s rank correlation was also examined.ResultsThe mean circulating irisin levels (ng/mL) were significantly higher in the normoglycemic (but not prediabetic) MetS group (p < 0.01), while the mean circulating FGF1 levels (pg/mL) were markedly lower in the prediabetic (but not normoglycemic) MetS group (p < 0.05). Of note unlike FGF1, irisin in the MetS (both normoglycemic and prediabetic;N=59) groups correlated significantly and positively with each of waist circumference (WC), hip circumference (HC), body mass index (BMI), body adiposity index (BAI) and high-density lipoprotein-cholesterol (HDL-C) but not the non-HDL-C. Distinctively MetS-irisin negatively associated with the non-HDL-C/HDL-C ratio, total cholesterol (TC)/HDL-C ratio and the low-density lipoprotein-cholesterol (LDL-C)/HDL-C ratio, but positively with the red cell distribution width (RDW). In the same pool of 59 MetS reruits; Neither biomarker had a relationship with the visceral adiposity index (VAI), the lipid accumulation product (LAP), the conicity index (CI), the waist-hip ratio (WHR), the waist-to-height ratio (WHtR), the blood ratios or the atherogenicity index of plasma (AIP).ConclusionsAs any potential molecular crosstalk of irisin and FGF1 in MetS or its related dysregularities cannot be ruled out; Conversely the utility of irisin and FGF1 as surrogate prognostic biomarkers and putative pharmacotherapeutic targets in the predtion/prevention/management of diabetes and MetS is strongly suggested. |
| Databáze: | OpenAIRE |
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