Sesamol Augments Paclitaxel-Induced Apoptosis in Human Cervical Cancer Cell Lines

Autor:	Jiayi Xiong, Juanjuan Sheng, Yan Wei, Zhimin Sun, Xia Xiao, Lanmei Zhang
Rok vydání:	2022
Předmět:	Cancer Research Nutrition and Dietetics Oncology Paclitaxel Phenols Medicine (miscellaneous) Animals Humans Uterine Cervical Neoplasms Apoptosis Female Benzodioxoles HeLa Cells
Zdroj:	Nutrition and cancer. 74(10)
ISSN:	1532-7914
Popis:	Natural medicinal compounds have gained increasing attention as adjuvants during cancer chemotherapy. The present study demonstrated the chemosensitizing effect of sesamol, a natural phenolic compound, in HeLa cell lines In Vitro. Sesamol-pretreated (10 μM) HeLa cells were exposed to 7.5 nM paclitaxel. The chemosensitization was estimated by MTT-based metabolic assay. Further, oxidative DNA damage, alterations in mitochondrial membrane potential (MMP), and apoptotic morphological changes were analyzed. Sesamol treatment before paclitaxel treatment significantly decreased the IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7428c5f12c945e49c6b775d7abebd130 https://pubmed.ncbi.nlm.nih.gov/35639488 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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