Association Between Motor Subtype and Visuospatial and Executive Function in Mild-Moderate Parkinson Disease
| Autor: | Madeleine E. Hackney, Chaejin Kim, Hannah Lally, Ariel R. Hart, Steven L. Wolf, Allison A. Bay |
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| Rok vydání: | 2020 |
| Předmět: |
Male
030506 rehabilitation medicine.medical_specialty Activities of daily living medicine.medical_treatment Trail Making Test Physical Therapy Sports Therapy and Rehabilitation Neuropsychological Tests Severity of Illness Index Antiparkinson Agents Executive Function 03 medical and health sciences symbols.namesake 0302 clinical medicine Physical medicine and rehabilitation medicine Humans Postural Balance Gait Disorders Neurologic Fisher's exact test Aged Retrospective Studies Balance (ability) Rehabilitation Montreal Cognitive Assessment Parkinson Disease Cognition Spatial cognition Middle Aged Agnosia symbols Female Cognition Disorders 0305 other medical science Psychology 030217 neurology & neurosurgery Spatial Navigation |
| Zdroj: | Archives of Physical Medicine and Rehabilitation. 101:1580-1589 |
| ISSN: | 0003-9993 |
| DOI: | 10.1016/j.apmr.2020.05.018 |
| Popis: | Objective To compare participants with Parkinson disease (PD) motor subtypes, postural instability and gait difficulty (PIGD) (n=46) and tremor dominant (TD) (n=28), in cognitive and motor-cognitive assessments with the purpose of identifying associations between subtype and visuospatial, whole-body spatial, inhibition and/or switching, and planning and/or organizational aspects of cognitive and motor-cognitive function. Design Retrospective cohort study. Fisher exact test was used for categorical variables, while 2-sample independent t tests were used to analyze continuous variables. Setting Assessments took place at Emory University. Participants Participants (N=72) were 40 years and older, had a clinical diagnosis of PD, exhibited 3 of the 4 cardinal signs of PD, had shown benefit from antiparkinsonian medications, and were in Hoehn and Yahr stages I-IV. Participants could walk 3 m or more with or without assistance. Interventions Not applicable. Main Outcome Measures Balance and mobility tests included Fullerton Advanced Balance Scale and the time needed to turn 360 degrees. Cognitive assessments included Montreal Cognitive Assessment, Brooks Spatial Memory Task, Color-Word Interference Test, Tower of London, Trail Making Test, Corsi Blocks, Serial 3s Subtraction, and Body Position Spatial Task. Motor-cognitive function measures included Four Square Step Test and Timed Up and Go. Results Participants with PIGD performed lower than those with TD symptoms on mental status (P=.005), spatial memory (P=.027), executive function (P=.0001-.034), and visuospatial ability (P=.048). Conclusions Findings suggest that PIGD subtype is linked to greater deficits in spatial cognition, attentional flexibility and organizational planning, and whole-body spatial memory domains. These findings support the need for more personalized approaches to clinically managing PD. |
| Databáze: | OpenAIRE |
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