Blood Pressure Lowering and Vasomodulator Effects of Piperine
| Autor: | Anwarul Hassan Gilani, Syed Intasar Husain Taqvi, Abdul Jabbar Shah |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Mean arterial pressure Polyunsaturated Alkamides Aorta Thoracic Blood Pressure Vasodilation In Vitro Techniques Pharmacology Rats Sprague-Dawley chemistry.chemical_compound Alkaloids Piperidines Coronary Circulation medicine.artery medicine Animals Benzodioxoles Phenylephrine Antihypertensive Agents Aorta Dose-Response Relationship Drug Chemistry Coronary Vessels Myocardial Contraction Rats Dose–response relationship Piperine Verapamil Cattle Rabbits medicine.symptom Piper nigrum Cardiology and Cardiovascular Medicine Vasoconstriction medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 52:452-458 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0b013e31818d07c0 |
| Popis: | This study was aimed to explore underlying mechanism(s) of cardiovascular effects of piperine. Intravenous administration of piperine caused a dose-dependent (1 to 10 mg/kg) decrease in mean arterial pressure (MAP) in normotensive anesthetized rats; the next higher dose (30 mg/kg) did not cause any further change in MAP. The fall in blood pressure (BP) was followed by small increase in MAP after each dose. In Langendorrf's rabbit heart preparation, piperine caused partial inhibition and verapamil caused complete inhibition of force and rate of ventricular contractions and coronary flow. In rabbit aortic rings, piperine inhibited high K+ (80 mM) precontractions and partially inhibited phenylephrine (PE), suggesting Ca2+ channel blockade (CCB), which was further confirmed when pretreatment of tissues with piperine caused rightward shift in Ca2+ concentration-response curves, similar to verapamil. In Ca2+-free medium, piperine (1 to 30 microM) exhibited vasoconstrictor effect. In rat aorta, piperine demonstrated endothelium-independent vasodilator effect and was more potent against high K+ precontractions than PE. In bovine coronary artery preparations, piperine inhibited high K+ precontractions completely. These data indicate that piperine possesses a blood pressure-lowering effect mediated possibly through CCB, while consistent decrease in BP was restricted by associated vasoconstrictor effect. Additionally, species selectivity exists in the CCB effect of piperine. |
| Databáze: | OpenAIRE |
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